ASYMMETRIC-SYNTHESIS .30. SYNTHESIS OF 3-SUBSTITUTED PIPERIDINES FROM CHIRAL NON-RACEMIC LACTAMS

被引：57

作者：

MICOUIN, L

VAREA, T

RICHE, C

CHIARONI, A

QUIRION, JC

HUSSON, HP

机构：

[1] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,CNRS,CHIM THERAPEUT LAB,F-75270 PARIS 06,FRANCE

[2] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 16期

关键词：

ASYMMETRIC SYNTHESIS; 3-SUBSTITUTED PIPERIDINES; DIASTEREOSELECTIVE ALKYLATION OF LACTAMS; STENUSINE;

D O I：

10.1016/S0040-4039(00)77162-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 3-substituted piperidines in enantiomerically pure form has been synthetized from lactam 3 by a stereospecific route involving a postulated rigid amide enolate. This strategy has been applied to the synthesis of (+)-stenusine 10.

引用

页码：2529 / 2532

页数：4

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