CHEMISTRY OF PENICILLANIC ACIDS .I. 6,6-DIBROMO- AND 6,6-DI-IODO-DERIVATIVES

被引：79

作者：

CLAYTON, JP

机构：

[1] Chemistry Department, Beecham Research Laboratories, Betchworth, Surrey

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 16期

关键词：

D O I：

10.1039/j39690002123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6,6-Dibromopenicillanic acid (IIIa) and 6,6-di-iodopenicillanic acid (IIIc) have been observed in the products of the deamination of 6β- aminopenicillanic acid (Ia) in the presence of sodium bromide and sodium iodide respectively. Deamination of (Ia) in the presence of bromine has resulted in the isolation of 6,6-dibromopenicillanic acid (IIIa) in 35% yield. The 1β-(Va) and 1α-(VIa) sulphoxides of this acid are described, together with some of its properties.

引用

页码：2123 / &

共 16 条

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