A STABLE L-ARGININE-DEPENDENT RELAXING FACTOR RELEASED FROM CYTOTOXIC-ACTIVATED MACROPHAGES

被引：13

作者：

UCHIZUMI, H ^{[1
]}

HATTORI, R ^{[1
]}

SASE, K ^{[1
]}

CAI, WJ ^{[1
]}

KADOTA, K ^{[1
]}

SASAYAMA, S ^{[1
]}

KAWAI, C ^{[1
]}

YUI, Y ^{[1
]}

机构：

[1] KYOTO UNIV, FAC MED, DEPT INTERNAL MED, DIV 3, KYOTO 60601, JAPAN

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 264卷 / 05期

关键词：

GUANOSINE; 3'; 5'-CYCLIC MONOPHOSPHATE; N(G)-MONO-METHYL-L-ARGININE; NITRIC OXIDE; STABLE RELAXING FACTOR;

D O I：

10.1152/ajpheart.1993.264.5.H1472

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

It has been known that cytotoxic-activated macrophages release an unstable vasorelaxing substance, nitric oxide. We have found that a more stable relaxing factor is released from those cells. This factor seems to be synthesized from L-arginine. It acts through the activation of soluble guanylate cyclase without affecting membrane potential. It has little charge at nearly neutral pH, and its molecular weight is <500.

引用

页码：H1472 / H1477

页数：6

共 17 条

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