ALBUMIN MICROSPHERES AND MICROCAPSULES - METHODOLOGY OF MANUFACTURING TECHNIQUES

被引：105

作者：

ARSHADY, R

机构：

[1] Department of Chemistry, Imperial College of Science, Technology and Medicine, London

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 14卷 / 02期

关键词：

albumin microcapsules; albumin micropspheres; biodegradation; chemical crosslinking; drug release; magnetite incorporation; multi-core capsules; particle size control; thermal crosslinking;

D O I：

10.1016/0168-3659(90)90149-N

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A methodological review of the preparation of albumin nano/microspheres and nano/microcapsules by suspension crosslinking is presented. Basic features of suspension crosslinking techniques, i.e. droplet formation and stabilization, particle size and size distribution, and droplet hardening are discussed. Droplet/particle size control by the adjustment of manufacturing parameters such as apparatus design, fluid viscosity, stabilizer and stirrer speed are analyzed. Typical procedures for the preparation of albumin nano/microspheres and nano/microcapsules (including magnetically sensitive ones) are discussed on the basis of the particle size range they produce and the type of oil phase they employ. Manufacturing problems, including microencapsulation of solid core materials, droplet coalescence, central or peripheral location of magnetic particles in albumin microcapsules, are illustrated and discussed. The dependence of microcapsule characteristics, namely hydration, biodegradability and core release, are also outlined. © 1990.

引用

页码：111 / 131

页数：21

共 51 条

[11] Arshady, Preparation of microspheres and microcapsules by interfacial polycondensation techniques, J. Microcaps., 6, pp. 13-28, (1989)
[12] Arshady, Polylactate and related microspheres and microcapsules: Methodology of manufacturing techniques, J. Controlled Release, (1990)
[13] Nixon, Preparation of microcapsules with possible Pharmaceutical use, Endeavour, New Ser., 9, 3, pp. 123-128, (1985)
[14] Chemtob, Microencapsulation par coacervation, Labo-Pharma-Probl. Tech., 32, 346, pp. 702-709, (1984)
[15] Arshady, Ledwith, Suspension polymerization and its application to the preparation of polymer supports, Reactive Polym., 1, pp. 159-174, (1983)
[16] Scully, Scale up in suspension polymerization, Journal of Applied Polymer Science, 20, pp. 2299-2303, (1976)
[17] Kafarov, Babanov, Phase contact area of immiscible liquids during agitation by mechanical stirrers, J. Appl. Chem. USSR, 32, pp. 810-814, (1959)
[18] Oldshue, Fluid Mixing Technology, Chemical Engineering, (1983)
[19] Longo, Iwata, Cindheimer, Goldberg, Preparation of hydrophilic albumin microspheres using polymeric dispersion agents, J. Pharm. Sci., 71, pp. 1323-1327, (1982)
[20] Widder, Fluoret, Senyei, Magnetic microspheres, J. Pharm. Sci., 68, pp. 79-82, (1979)

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