DEFICIENCY OF COMPLEMENT DECAY-ACCELERATING FACTOR (DAF, CD55) IN NON-HODGKINS-LYMPHOMA

被引：12

作者：

FUKUDA, H

SEYA, T

HARA, T

MATSUMOTO, M

KINOSHITA, T

MASAOKA, T

机构：

[1] CTR ADULT DIS,DEPT IMMUNOL,HIGASHINARI KU,OSAKA 537,JAPAN

[2] CTR ADULT DIS,DEPT HEMATOL,OSAKA 537,JAPAN

[3] OSAKA UNIV,MICROBIAL DIS RES INST,SUITA,OSAKA 565,JAPAN

来源：

IMMUNOLOGY LETTERS | 1991年 / 29卷 / 03期

关键词：

DEPOSITION OF COMPLEMENT C3; DECAY-ACCELERATING FACTOR (DAF; CD55); MEMBRANE COFACTOR PROTEIN (MCP; CD46); NON-HODGKINS LYMPHOMA;

D O I：

10.1016/0165-2478(91)90171-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have assessed levels of surface-expressed complement regulatory proteins, decay-accelerating factor (DAF) and membrane cofactor protein (MCP) on cells from patients with hematological malignancies. Neither malignant cells nor unaffected nucleated blood cells from the patients lacked MCP. On the other hand, complete deficiency of DAF was found in 2/10 of non-Hodgkin's lymphoma (NHL), while none of the 38 patients with acute nonlymphocytic leukemia (ANLL) (14 cases), chronic myelogenous leukemia (CML) (6 cases), acute lymphocytic leukemia (ALL) (12 cases) and chronic lymphocytic leukemia (CLL) (6 cases) lacked DAF. The two patients with DAF-negative NHL had no history of paroxysmal nocturnal hemoglobinuria (PNH), and their peripheral blood cells were DAF-positive. One DAF-negative NHL exhibited T cell markers and the other those of B cell. In both cases, treatment of the DAF-negative lymphoma cells with antibody against MCP (M177) followed by Mg2+-EGTA-serum resulted in efficient deposition of homologous C3. These results infer that some NHL specifically lack DAF and, through treatment with M177, are targeted by homologous C3.

引用

页码：205 / 210

页数：6

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