MECHANISM OF THE POSTRECEPTOR DEFECT IN INSULIN ACTION IN HUMAN OBESITY - DECREASE IN GLUCOSE-TRANSPORT SYSTEM ACTIVITY

被引：112

作者：

CIARALDI, TP ^{[1
]}

KOLTERMAN, OG ^{[1
]}

OLEFSKY, JM ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DIV ENDOCRINOL METAB,DENVER,CO 80262

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1981年 / 68卷 / 04期

关键词：

D O I：

10.1172/JCI110342

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

收藏

页码：875 / 880

页数：6

相关论文

共 19 条

[1] INSULIN-STIMULATED GLUCOSE-TRANSPORT IN HUMAN ADIPOCYTES
CIARALDI, TP
KOLTERMAN, OG
SIEGEL, JA
OLEFSKY, JM
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1979, 236 (06): : E621 - E625
[2] CUSHMAN SW, 1980, J BIOL CHEM, V255, P4758
[3] MONOIODOINSULIN - DEMONSTRATION OF ITS BIOLOGICAL ACTIVITY AND BINDING TO FAT CELLS AND LIVER MEMBRANES
FREYCHET, P
ROTH, J
NEVILLE, DM
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1971, 43 (02) : 400 - &
[4] BINDING AND DEGRADATION OF I-125-LABELED INSULIN BY ISOLATED RAT FAT-CELLS
GAMMELTOFT, S
GLIEMANN, J
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 320 (01) : 16 - 32
[5] CORRELATION BETWEEN INSULIN RECEPTOR-BINDING IN ISOLATED FAT-CELLS AND INSULIN SENSITIVITY IN OBESE HUMAN SUBJECTS
HARRISON, LC
MARTIN, FIR
MELICK, RA
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (06) : 1435 - 1441
[6] HIRSCH J, 1968, J LIPID RES, V9, P110
[7] KAHN CR, 1978, METABOLISM, V27, P1893
[8] MECHANISMS OF INSULIN RESISTANCE IN HUMAN OBESITY - EVIDENCE FOR RECEPTOR AND POSTRECEPTOR DEFECTS
KOLTERMAN, OG
INSEL, J
SAEKOW, M
OLEFSKY, JM
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1980, 65 (06) : 1272 - 1284
[9] RELATIONSHIP BETWEEN INVIVO INSULIN RESISTANCE AND DECREASED INSULIN RECEPTORS IN OBESE MAN
KOLTERMAN, OG
REAVEN, GM
OLEFSKY, JM
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1979, 48 (03) : 487 - 494
[10] KONO T, 1971, J BIOL CHEM, V246, P6210