BIOSENSOR MONITORING OF BLOOD LACTATE DURING OPEN-HEART-SURGERY

被引：9

作者：

KYROLAINEN, M

HAKANSON, H

EKROTH, R

MATTIASSON, B

机构：

[1] Department of Biotechnology, Chemical Centre, Lund University, S-221 00 Lund

来源：

ANALYTICA CHIMICA ACTA | 1993年 / 279卷 / 01期

关键词：

BIOSENSORS; ENZYMATIC METHODS; BLOOD; ENZYME REACTOR; LACTATE; SURGERY;

D O I：

10.1016/0003-2670(93)85077-W

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An on-line monitoring system for lactate in blood is described. The system consists of a sampling unit allowing dilution at the sampling point, a sample treatment unit for dialysis of the sample and an enzyme reactor with immobilized lactate oxidase. A Clark electrode is used as transducer. The enzyme preparation shows high storage stability and good operational stability. The system was used, during and after open-heart surgery, to follow fluctuation in the concentrations Of L-lactate in blood being pumped to and from the brain. A small difference of approximately 0.3-0.5 mM was monitored.

引用

页码：149 / 153

页数：5

共 8 条

[1] HAKANSON H, 1988, METHOD ENZYMOL, V137, P319
[2] HAKANSON H, IN PRESS BIOSENSORS
[3] MASCINI M, 1987, CLIN CHEM, V33, P591
[4] PALLESCHI G, 1989, ANAL LETT, V22, P1209
[5] AMPEROMETRIC ASSAY OF GLUCOSE AND LACTIC-ACID BY FLOW-INJECTION ANALYSIS
PETERSSON, BA
[J]. ANALYTICA CHIMICA ACTA, 1988, 209 (1-2) : 231 - 237
[6] ONLINE ANALYSIS AND CONTROL OF PRODUCTION OF ANTIBIOTICS
SCHUGERL, K
[J]. ANALYTICA CHIMICA ACTA, 1988, 213 (1-2) : 1 - 9
[7] CONTINUOUS MONITORING OF UREA IN BLOOD DURING DIALYSIS
THAVARUNGKUL, P
HAKANSON, H
HOLST, O
MATTIASSON, B
[J]. BIOSENSORS & BIOELECTRONICS, 1991, 6 (02) : 101 - 107
[8] Weetall H H, 1976, Methods Enzymol, V44, P134

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