CONDENSATION-INHIBITION BY 33258-HOECHST OF CENTROMERIC HETEROCHROMATIN IN PREMATURELY CONDENSED MOUSE CHROMOSOMES

被引：21

作者：

MARCUS, M ^{[1
]}

SPERLING, K ^{[1
]}

机构：

[1] FREE UNIV BERLIN,INST HUMAN GENET,D-1000 BERLIN 33,FED REP GER

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 123卷 / 02期

关键词：

D O I：

10.1016/0014-4827(79)90488-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The phenomenon of premature chromosome condensation has been applied to study the kinetics of condensation-inhibition exerted by the fluorochrome 33258-Hoechst (33258-H) on the centromeric heterochromatic regions of mouse chromosomes. Asynchronous mouse A-9 cells in culture were fused with mitotic HeLa cells in the presence of 33258-H. Pronounced condensation-inhibition of the c-heterochromatin was observed in prematurely condensed early G2, S and late G1 chromosomes in the 33258-H-treated cells. It is concluded that the c-heterochromatic regions begin to condense quite early in G2, decondense again late in G1 and remain decondensed in the S phase. © 1979.

引用

页码：406 / 411

页数：6

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