GENOTOXIC EFFECTS OF SODIUM ARSENITE ON HUMAN-CELLS

被引：141

作者：

JHA, AN

NODITI, M

NILSSON, R

NATARAJAN, AT

机构：

[1] LEIDEN UNIV,DEPT RADIAT GENET & CHEM MUTAGENESIS,WASSENAARSWEG 72,2333 AL LEIDEN,NETHERLANDS

[2] INTERUNIV RES INST RADIOPATHOL & RADIAT PROTECT,JA COHEN INST,LEIDEN,NETHERLANDS

[3] NATL SWEDISH CHEM INSPECTORATE,DIV SCI DOCUMENTAT & RES,SOLNA,SWEDEN

来源：

MUTATION RESEARCH | 1992年 / 284卷 / 02期

关键词：

SODIUM ARSENITE; CHROMOSOMAL ABERRATIONS; SISTER-CHROMATID EXCHANGES; MICRONUCLEUS TEST;

D O I：

10.1016/0027-5107(92)90005-M

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effects of sodium arsenite (SA) were studied either alone or in combination with X-rays in peripheral blood lymphocytes, and with short-wave ultraviolet (UV) radiation in primary human fibroblast culture systems. It was found that SA (i) inhibited the cell cycle progression of phytohaemagglutinin (PHA)-responsive lymphocytes, (ii) induced chromatid-type aberrations and sister-chromatid exchanges (SCEs) as a function of concentration and (iii) potentiated the X-ray- and UV-induced chromosomal damage. Our results suggest that SA interferes with the DNA repair process, presumably by inhibiting the ligase activity. This accounted for an increase in the DNA replication-dependent processes, chromatid aberrations and SCEs and synergistic enhancement of the X-ray- and UV-induced chromosomal damage. This ability of arsenite may be responsible for its comutagenic properties with different types of mutagens and hence its carcinogenicity.

引用

页码：215 / 221

页数：7