LYOAVAILABILITY OF NORDAZEPAM SOLID DISPERSIONS IN RELATION WITH PHASE-DIAGRAMS

被引：1

作者：

ELMOUSSAOUI, A

CHAUVET, A

MASSE, J

GAUDY, D

PUECH, A

机构：

[1] FAC PHARM MONTPELLIER,CHIM GEN & MINERALE LAB,F-34060 MONTPELLIER 1,FRANCE

[2] FAC PHARM MONTPELLIER,PHARM GALEN PHARMACOTECHN & BIOPHARM LAB,F-34060 MONTPELLIER 1,FRANCE

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 106卷 / 02期

关键词：

NORDAZEPAM; SOLID DISPERSION; LYOAVAILABILITY;

D O I：

10.1016/0378-5173(94)90308-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have prepared solid dispersions (melt, coprecipitate) of nordazepam III (NDZ) with carriers polyoxyethylene glycol (PEG 6000), succinic acid, and with another drug, nicotinic acid, corresponding to the eutectic composition. From a study of the dissolution kinetics, we found that the highest value is obtained for the PEG 6000 melt. We have shown that there is a good correlation between PEG solid dispersion dissolution kinetics and mixing enthalpies.

引用

页码：109 / 114

页数：6

共 10 条

[1] THERMOANALYTICAL AND SPECTRAL STUDY OF BENZODIAZEPINES .2. NORDAZEPAM [J].