CONCAVE FUNCTIONALITY - DESIGN CRITERIA FOR NONAQUEOUS BINDING-SITES

被引：122

作者：

WHITLOCK, BJ ^{[1
]}

WHITLOCK, HW ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT CHEM,MCELVAIN LABS ORGAN CHEM,MADISON,WI 53706

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1990年 / 112卷 / 10期

关键词：

D O I：

10.1021/ja00166a027

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and phenol-binding properties of cyclophane hosts 1a and 1b are described. A sliding scale method for determining binding constants of the hosts is described. Host 1a with p-nitrophenol has a binding constant of ca. 96000 M–1. The significance of this result with respect to the design of sites capable of molecular recognition is discussed. © 1990, American Chemical Society. All rights reserved.

引用

页码：3910 / 3915

页数：6

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