SYNTHESIS OF INVIVO POTENT ANTIMALARIAL 1,2,4-TRIOXANES

被引：49

作者：

SINGH, C ^{[1
]}

MISRA, D ^{[1
]}

SAXENA, G ^{[1
]}

CHANDRA, S ^{[1
]}

机构：

[1] CENT DRUG RES INST,DIV PARASITOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80177-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Beta-hydroxyhydroperoxides (5a-h) derived from 3-aryl-2-butenol (6a-h) by dye-sensitized photooxygenation undergo a facile acid-catalysed condensation with 2-adamantanone to yield 1,2,4-trioxanes (8a-h). These trioxanes are stable at room temperature, can be stored in refrigerator for a year and are active against Plasmodium berghei in mice.

引用

页码：497 / 500

页数：4

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