DEVELOPMENTAL EXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA BY NEURONS OF FETAL AND ADULT MONKEY PREFRONTAL CORTEX

被引：62

作者：

HUNTLEY, GW

BENSON, DL

JONES, EG

ISACKSON, PJ

机构：

[1] UNIV CALIF IRVINE,DEPT ANAT & NEUROBIOL,IRVINE,CA 92717

[2] UNIV CALIF IRVINE,DEPT BIOL CHEM,IRVINE,CA 92717

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1992年 / 70卷 / 01期

基金：

美国国家卫生研究院;

关键词：

GROWTH FACTOR; GENE EXPRESSION; CORTICAL DEVELOPMENT; INSITU HYBRIDIZATION; PRIMATE;

D O I：

10.1016/0165-3806(92)90103-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In situ hybridization histochemistry with labeled cRNA probes complementary to monkey brain derived neurotrophic factor (BDNF) mRNAs has been used to study the cellular localization and expression of this neurotrophin in the prefrontal cerebral cortex of fetal and adult monkeys. Expression could not be detected in prefrontal cortex before the 121st fetal day. Thereafter, in fetal life and in adulthood BDNF mRNA could be detected primarily in large, putative pyramidal cells of layers III and VI throughout the prefrontal cortex. The temporal course and cellular localization of BDNF expression suggests its association with the development and stabilization of specific connections in regions of cortex that display marked functional plasticity.

引用

页码：53 / 63

页数：11

共 95 条

[1] BRAIN-DERIVED NEUROTROPHIC FACTOR INCREASES SURVIVAL AND DIFFERENTIATED FUNCTIONS OF RAT SEPTAL CHOLINERGIC NEURONS IN CULTURE [J].