EXPRESSION OF CYTOKINE RECEPTORS IN CULTURED NEURONAL AND GLIAL-CELLS

被引：149

作者：

SAWADA, M ^{[1
]}

ITOH, Y ^{[1
]}

SUZUMURA, A ^{[1
]}

MARUNOUCHI, T ^{[1
]}

机构：

[1] FUJITA HLTH UNIV,SCH MED,DEPT NEUROL,TOYOAKE,AICHI 47011,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 160卷 / 02期

关键词：

CYTOKINE RECEPTOR; MICROGLIA; ASTROCYTE; OLIGODENDROCYTE; NEURON; CYTOKINE NETWORK;

D O I：

10.1016/0304-3940(93)90396-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated mRNA expression of cytokine receptors in three different types of glial cells and two neuronal line cells by the RT-PCR method. Microglia expressed mRNA for receptors of IL-3, -4, -6, -7, GM-CSF, and M-CSF. Astrocytes were positive for receptors of IL-6, -7, GM-CSF, and M-CSF. Oligodendrocytes were positive for receptors of IL-3, -4, -7, GM-CSF, and M-CSF. Neuronal cells expressed receptors of IL-6 and GM-CSF with very low levels. This is the first demonstration of cytokine receptor mRNA expression in isolated glial and neuronal cells.

引用

页码：131 / 134

页数：4

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