MICTURITION PATTERNS AFTER SPINAL TRAUMA AS A MEASURE OF AUTONOMIC FUNCTIONAL RECOVERY

被引:27
作者
CHANCELLOR, MB
RIVAS, DA
HUANG, B
KELLY, G
SALZMAN, SK
机构
[1] THOMAS JEFFERSON UNIV,DEPT UROL,PHILADELPHIA,PA 19107
[2] ALFRED I DUPONT INST,SPINAL RES PROGRAM,WILMINGTON,DE 19899
关键词
SPINAL CORD INJURIES; BLADDER; NEUROGENIC; URODYNAMICS; URINATION;
D O I
10.1016/S0022-5347(17)34926-1
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The purpose of these experiments was to determine whether experimental spinal trauma would result in urological dysfunction similar to that seen clinically and whether recovery of normal micturition can be correlated with motor functional recovery. A standard rat model of spinal impact trauma was employed. Neurologic evaluation included a modified 7 point hindlimb Tarlov scale applied weekly for 4 weeks after injury. Micturition measurement was accomplished by placing the animal in a metabolic cage for 24-hour periods and collecting urine on an electronic scale connected to Lotus Measure data acquisition software. All assessments were performed in a blinded fashion. Animals were categorized as normal control (N = 10), sham injured (N = 11), spinal cord injury (SCI) without (N = 11) and with locomotor recovery (N = 11). There were no differences in total micturition volume among the 4 groups, while the number of micturitions per 24 hours was significantly less for SCI without locomotor recovery (10.4 +/- 5.9) than for control (21.3 +/- 4.5). The volume per micturition was significantly greater for SCI (2.0 +/- 0.7 ml.) than for control (0.8 +/- 0.2 ml.). There were no differences among groups in the ratio of number of micturitions night/day. The SCI group had significantly greater largest and smallest micturitional volumes. Results clearly show alterations in micturition patterns induced by SCI. These were proportional to, but did not correlate fully with, the severity of injury and degree of motor recovery. Thus, recovery of a normal micturition pattern did not occur to the same extent as did motor functional recovery. This difference underscores the potential value of autonomic measures of SCI for distinguishing outcome categories after experimental SCI.
引用
收藏
页码:250 / 254
页数:5
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