LITHIUM (ALPHA-METHYLBENZYL)ALLYLAMIDE - A DIFFERENTIALLY PROTECTED CHIRAL AMMONIA EQUIVALENT FOR THE ASYMMETRIC-SYNTHESIS OF BETA-AMINO ACIDS AND BETA-LACTAMS

被引：76

作者：

DAVIES, SG

FENWICK, DR

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 11期

关键词：

D O I：

10.1039/c39950001109

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The addition products from the highly stereoselective conjugate additions of lithium (alpha S)-(alpha-methylbenzyl)allylamide to alpha,beta-unsaturated tert-butyl esters are efficiently deallylated with tris(triphenylphosphine)rhodium(I) chloride and converted, after transesterification to the methyl esters and cyclisation with methylmagnesium bromide, to the corresponding homochiral N-(alpha-methylbenzyl)-4-substituted-azetidin-2-ones.

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页码：1109 / 1110

页数：2

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