THE PROGNOSTIC VALUE OF DNA-PLOIDY IN COLORECTAL-CARCINOMA - A PROSPECTIVE-STUDY

被引：67

作者：

KOURI, M

PYRHONEN, S

MECKLIN, JP

JARVINEN, H

LAASONEN, A

FRANSSILA, K

NORDLING, S

机构：

[1] HELSINKI UNIV,CENT HOSP,DEPT ONCOL,SF-02900 HELSINKI,FINLAND

[2] UNIV HELSINKI,DEPT RADIOTHERAPY & ONCOL,PATHOL LAB,SF-00100 HELSINKI 10,FINLAND

[3] UNIV HELSINKI,DEPT PATHOL,SF-00100 HELSINKI 10,FINLAND

[4] HELSINKI UNIV,CENT HOSP,DEPT SURG 2,SF-02900 HELSINKI,FINLAND

来源：

BRITISH JOURNAL OF CANCER | 1990年 / 62卷 / 06期

关键词：

D O I：

10.1038/bjc.1990.420

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One hundred and fifty-seven patients with usual colorectal cancer were analysed prospectively for DNA-ploidy, DNA-index and S-phase fraction (SPF) using flow cytometry. An abnormal DNA-stemline was observed in 68% of tumours. The patients have been followed for a median of 36 months. In univariate analysis, tumour stage was the most significant prognostic factor. After excluding patients with stage D disease, DNA-aneuploidy was significantly associated with a shorter survival and a shorter disease free survival. SPF, however, did not correlate with prognosis. In multiple samples from the same tumour there was on average a 29% difference between the highest and the lowest SPF indicating considerable heterogeneity in proliferative activity within the tumours. In diploid tumours the variation was even higher. Patients with proximal tumours as well as female patients had DNA-diploid tumours more often than the others. This may indicate that there are different, so far unknown, aetiological factors leading to different types of ploidy pattern. © Macmillan Press Ltd., 1990.

引用

页码：976 / 981

页数：6

共 30 条

[21] SURVIVAL OF LARGE-BOWEL CARCINOMA PATIENTS WITH DIFFERENT DNA PLOIDY [J].

ROGNUM, TO ;

THORUD, E ;

LUND, E .

BRITISH JOURNAL OF CANCER, 1987, 56 (05) :633-636

[22]

SCHUTTE B, 1987, CANCER RES, V47, P5494

[23] THE RELATIVE PROGNOSTIC VALUE OF FLOW CYTOMETRIC DNA ANALYSIS AND CONVENTIONAL CLINICOPATHOLOGICAL CRITERIA IN PATIENTS WITH OPERABLE RECTAL-CARCINOMA [J].

SCOTT, NA ;

RAINWATER, LM ;

WIEAND, HS ;

WEILAND, LH ;

PEMBERTON, JH ;

BEART, RW ;

LIEBER, MM .

DISEASES OF THE COLON & RECTUM, 1987, 30 (07) :513-520

[24]

SCOTT NA, 1987, ARCH SURG-CHICAGO, V122, P1375

[25]

SECKINGER D, 1989, ARCH PATHOL LAB MED, V113, P619

[26]

SHAPIRO HM, 1989, ARCH PATHOL LAB MED, V113, P591

[27] STANDARDIZATION OF HIGH-RESOLUTION FLOW CYTOMETRIC DNA ANALYSIS BY THE SIMULTANEOUS USE OF CHICKEN AND TROUT RED-BLOOD-CELLS AS INTERNAL REFERENCE-STANDARDS [J].

VINDELOV, LL ;

CHRISTENSEN, IJ ;

NISSEN, NI .

CYTOMETRY, 1983, 3 (05) :328-331

[28]

WIGGERS T, 1988, CANCER, V61, P386, DOI 10.1002/1097-0142(19880115)61:2<386::AID-CNCR2820610231>3.0.CO

[29]

2-J

[30]

WOLLEY RC, 1982, J NATL CANCER I, V69, P15

← 1 2 3 →