THE ROLE OF ENDOGENOUS PROSTAGLANDINS IN HORMONE-STIMULATED PANCREATIC EXOCRINE SECRETION

被引:6
作者
BEAUCHAMP, RD [1 ]
MACLELLAN, DG [1 ]
UPP, JR [1 ]
NEALON, WH [1 ]
TOWNSEND, CM [1 ]
THOMPSON, JC [1 ]
机构
[1] UNIV TEXAS, MED BRANCH, DEPT SURG, GALVESTON, TX 77550 USA
关键词
D O I
10.1016/0016-5085(92)91810-Q
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The authors have previously shown that neurotensin and secretin inhibit gastric acid secretion in the dog and that these actions are inhibited by the prostaglandin synthesis inhibitor indomethacin. Conversely, neurotensin and secretin share similar stimulatory effects on pancreatic exocrine secretion. In the present study, the effects of blockade of prostaglandin synthesis by indomethacin on neurotensin-, cholecystokinin-, and secretin-stimulated exocrine secretion are examined along with the effects of these same agents on the release of pancreatic polypeptide. The studies were performed on conscious dogs with chronic gastric and pancreatic cannulas. Dose-dependent increases in pancreatic exocrine secretion of water and bicarbonate were observed with IV infusion of neurotensin or secretin; however, inhibition of prostaglandin synthesis by indomethacin abolished this response. Protein secretion stimulated by either neurotensin or cholecystokinin was not affected by prostaglandin inhibition. Cholecystokinin and neurotensin infusion stimulated release of pancreatic polypeptide; only neurotensin-stimulated release of pancreatic polypeptide was inhibited by indomethacin treatment. It is concluded that intact prostaglandin synthesis is necessary for the actions of neurotensin and secretin (but not that of cholecystokinin) on pancreatic exocrine secretion of water and bicarbonate and for neurotensin- (but not cholecystokinin-) stimulated release of pancreatic polypeptide. © 1992.
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页码:272 / 279
页数:8
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