CLASTOGENICITY OF 2-CHLOROBENZYLIDENE MALONITRILE (CS) IN V79 CHINESE-HAMSTER CELLS

被引：5

作者：

BAUCHINGER, M

SCHMID, E

机构：

[1] Institut für Strahlenbiologie, GSF-Forschungszentrum für Umwelt und Gesundheit mbH, Neuherberg

来源：

MUTATION RESEARCH | 1992年 / 282卷 / 04期

关键词：

2-CHLOROBENZYLIDENE MALONITRILE; V79; CELLS; CLASTOGENICITY;

D O I：

10.1016/0165-7992(92)90127-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The clastogenicity of the sensory irritant 2-chlorobenzylidene malonitrile (CS) to V79 Chinese hamster cells was investigated at various exposure conditions. CS efficiently induced chromatid-type aberrations in a dose-dependent manner provided the cells could run through at least one or two S-phases during a 20-h exposure over a 3-h exposure followed by a 20-h recovery period (cell cycle time 8-10 h). The induction of SCEs indicates an S-dependent mechanism. The hydrolysis products o-chlorobenzaldehyde and malonitrile were inactive in these experiments.

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页码：231 / 234

页数：4

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