ANTI-AIDS AGENTS .6. SALASPERMIC ACID, AN ANTI-HIV PRINCIPLE FROM TRIPTERYGIUM-WILFORDII, AND THE STRUCTURE-ACTIVITY CORRELATION WITH ITS RELATED-COMPOUNDS

被引：45

作者：

CHEN, K

KASHIWADA, Y

ZHANG, DC

HU, CQ

JIN, JQ

NOZAKI, H

KILKUSKIE, RE

TRAMONTANO, E

CHENG, YC

MCPHAIL, DR

MCPHAIL, AT

LEE, KH

SHI, Q

机构：

[1] DUKE UNIV,PAUL M GROSS CHEM LAB,DEPT CHEM,DURHAM,NC 27706

[2] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

[3] SHANGHAI MED UNIV,SCH PHARM,DEPT CHEM NAT DRUGS,SHANGHAI 200032,PEOPLES R CHINA

[4] OKAYAMA UNIV SCI,FAC SCI,DEPT BIOL CHEM,OKAYAMA 700,JAPAN

[5] CAMBRIDGE BIOTECH CORP,ROCKVILLE,MD 20850

[6] YALE UNIV,SCH MED,DEPT PHARMACOL,NEW HAVEN,CT 06510

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 03期

关键词：

D O I：

10.1021/np50081a010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Salaspermic acid [1], an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells, was isolated from the roots of Tripterygium wilfordii for the first time. The structure of 1 derived from spectral data was established unequivocally by an X-ray analysis of crystals of the monohydrate. A structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring A and the carboxyl group in ring E of 1 may be required for the anti-HIV activity.

引用

页码：340 / 346

页数：7

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