SERUM CONCENTRATIONS OF PENICILLIN, DOXYCYCLINE, AND CIPROFLOXACIN DURING PROLONGED THERAPY IN RHESUS-MONKEYS

被引：37

作者：

KELLY, DJ ^{[1
]}

CHULAY, JD ^{[1
]}

MIKESELL, P ^{[1
]}

FRIEDLANDER, AM ^{[1
]}

机构：

[1] USA MED RES INST INFECT DIS,DIV BACTERIOL,FT DETRICK,MD

来源：

JOURNAL OF INFECTIOUS DISEASES | 1992年 / 166卷 / 05期

关键词：

D O I：

10.1093/infdis/166.5.1184

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Concentrations of penicillin, doxycycline, and ciprofloxacin were measured by bioassay in sera of rhesus monkeys treated with these drugs for inhalation anthrax. Antibiotic doses were determined on the basis of published serum concentration data from humans and comparative body surface area calculations for humans and rhesus monkeys. The antibiotics were well tolerated. Serum peak and trough concentrations of penicillin, doxycycline, and ciprofloxacin, respectively, averaged 2.7 and 0.8, 1.31 and 0.26, and 1.22 and 0.14 mug/mL. These were within the range usually observed with standard oral doses in humans, and peak concentrations in all monkeys exceeded the MICs for 90% of Bacillus anthracis strains.

引用

页码：1184 / 1187

页数：4