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IMMUNOEPIDEMIOLOGY OF INTESTINAL HELMINTHIC INFECTIONS .2. IMMUNOLOGICAL CORRELATES WITH PATTERNS OF TRICHURIS INFECTION

被引：15
作者：
NEEDHAM, CS [1 ]
LILLYWHITE, JE [1 ]
机构：
[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, DEPT BIOL, WELLCOME RES CTR PARASIT INFECT, LONDON SW7 2BB, ENGLAND
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1994年 / 88卷 / 03期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/0035-9203(94)90071-X
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The significance of parasite-specific serum and secretory immunoglobulin (Ig) isotype responses as determinants of Trichuris trichiura infection intensity in endemic communities is discussed. Comparison of age-dependent isotype responses and the age profiles of infection intensity in 2 endemic communities with markedly different levels of T. trichiura transmission suggest that serum IgA responses may reflect the accumulated past experience of infection and thus may be relevant in acquired immunity to T. trichiura and contribute to the age-convexity of infection intensity in areas of intense transmission. Preliminary analysis of data from a second community-based study shows that parasite-specific secretory IgA in saliva increases with age and correlates negatively with infection intensity, suggesting that secretory IgA may also be implicated in acquired immunity to this gut-dwelling nematode.
引用
收藏
页码：262 / 264
页数：3
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