CHRONIC STRESS AND MEMORY - IMPLICATION OF THE CENTRAL CHOLINERGIC SYSTEM

被引：13

作者：

ZERBIB, R ^{[1
]}

LABORIT, H ^{[1
]}

机构：

[1] HOP BOUCICAULT,EUTONOL LAB,78 RUE CONVENT,F-75730 PARIS 15,FRANCE

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 04期

关键词：

Cholinergic system; Chronic restraint stress; Memory; Oxotremorine; Scopolamine;

D O I：

10.1016/0091-3057(90)90097-2

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Restraint stress for ten days (two times two hours daily) induces a hypersensitivity of the central cholinergic system, reflected by antagonism to amnesia induced by scopolamine at 0.1 mg/kg in a passive avoidance test and by hypersensitivity to the hypothermic effect of oxotremorine at 1 mg/kg. A restraint stress for 30 days, on the other hand, diminishes animal retention in the passive avoidance test and causes a hyposensitivity to oxotremorine-induced hypothermia, reflecting a hypoactivity of the central cholinergic system. An acute 24-hour stress causes no change. The relationship between chronic stress and associated memory deficits is discussed. © 1990.

引用

页码：897 / 900

页数：4