ANALYSIS OF DOUBLE-STRANDED OLIGONUCLEOTIDES BY ELECTROSPRAY MASS-SPECTROMETRY

被引：74

作者：

BAYER, E

BAUER, T

SCHMEER, K

BLEICHER, K

MALER, M

GAUS, HJ

机构：

[1] Institute of Organic Chemistry, Universitat Tubingen, 72076 Tubingen

来源：

ANALYTICAL CHEMISTRY | 1994年 / 66卷 / 22期

关键词：

D O I：

10.1021/ac00094a004

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Double-stranded oligonucleotides of different lengths and chemical modification have been analyzed by ion spray mass spectrometry. The non-covalent-bonded duplexes can be detected. Therefore, ion spray mass spectrometry is a useful method for investigation of hybridizations of natural and chemically modified oligonucleotides. Since the exact mass of the double strand can be detected, this method can distinguish between specific and nonspecific interaction.

引用

页码：3858 / 3863

页数：6

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