ANALYSIS OF THE BCL-6 GENE CONFIGURATION IN DIFFUSE B-CELL NON-HODGKINS-LYMPHOMAS AND HODGKINS-DISEASE

被引:12
作者
PESCARMONA, E
LOCOCO, F
PACCHIAROTTI, A
RAPANOTTI, MC
CIMINO, G
DIPAOLO, B
BARONI, CD
机构
[1] UNIV ROMA LA SAPIENZA,DEPT EXPTL MED,ROME,ITALY
[2] UNIV ROMA LA SAPIENZA,DEPT HAEMATOL,ROME,ITALY
[3] UNIV ROMA LA SAPIENZA,DEPT HUMAN BIOPATHOL,ROME,ITALY
关键词
BCL-6; ONCOGENES; NON-HODGKINS LYMPHOMAS; HODGKINS DISEASE;
D O I
10.1002/path.1711770105
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BCL-6 is a novel proto-oncogene that codes for a zinc-finger protein sharing homologies with many transcription factors. It has recently been shown that BCL-6 is involved in chromosome band 3q27 aberrations in non-Hodgkin's lymphomas (NHLs) and BCL-6 rearrangements have been detected in 34-45 per cent of diffuse large cell lymphomas with B immunophenotype. We have studied the BCL-6 gene configuration by Southern blot analysis in 60 cases of B-cell NHL and in 17 cases of Hodgkin's disease (HD). BCL-6 was rearranged in 15/46 (32.6 per cent) diffuse B-large cell lymphomas, mainly with centroblastic morphology, and in 2/11 (18.2 per cent) follicular (centroblastic-centrocytic) lymphomas. Conversely, all cases of HD, including four cases of lymphocyte predominant, nodular type (nodular paragranuloma), had a germline configuration. These findings confirm that BCL-6 is rearranged in a significant percentage of diffuse B-large cell lymphomas, suggesting that this proto-oncogene might have a pathogenetic role in this subset of NHLs, but our preliminary analysis suggests that BCL-6 lesions are not involved in the pathogenesis of HD. However, further investigations using more sensitive techniques are required to confirm these findings.
引用
收藏
页码:21 / 25
页数:5
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