STABILIZATION OF INSULIN UPON SUPRAMOLECULAR COMPLEXATION WITH HYDROPHOBIZED POLYSACCHARIDE NANOPARTICLE

被引:22
作者
AKIYOSHI, K [1 ]
NISHIKAWA, T [1 ]
SHICHIBE, S [1 ]
SUNAMOTO, J [1 ]
机构
[1] KYOTO UNIV,GRAD SCH ENGN,DIV SYNTHET CHEM & BIOL CHEM,SAKYO KU,KYOTO 60601,JAPAN
关键词
D O I
10.1246/cl.1995.707
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The hydrogel nanoparticle that was formed by self-assembly of cholesterol-bearing pullulan complexed with 5 - 10 insulin monomers in water. Biocolloidal and thermal stability of insulin drastically increased upon the supramolecular assembly with the hydrophobized polysaccharide.
引用
收藏
页码:707 / 708
页数:2
相关论文
共 11 条
[1]   SELF-AGGREGATES OF HYDROPHOBIZED POLYSACCHARIDES IN WATER - FORMATION AND CHARACTERISTICS OF NANOPARTICLES [J].
AKIYOSHI, K ;
DEGUCHI, S ;
MORIGUCHI, N ;
YAMAGUCHI, S ;
SUNAMOTO, J .
MACROMOLECULES, 1993, 26 (12) :3062-3068
[2]   SELF-ASSEMBLY OF HYDROPHOBIZED POLYSACCHARIDE - STRUCTURE OF HYDROGEL NANOPARTICLE AND COMPLEXATION WITH ORGANIC-COMPOUNDS [J].
AKIYOSHI, K ;
DEGUCHI, S ;
TAJIMA, H ;
NISHIKAWA, T ;
SUNAMOTO, J .
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1995, 71 (01) :15-19
[3]   SOLUTION PROPERTY OF HYDROPHOBIZED PULLULAN CONJUGATED WITH POLY(ETHYLENE OXIDE) POLY(PROPYLENE OXIDE) POLY(ETHYLENE OXIDE) BLOCK-COPOLYMER - FORMATION OF NANOPARTICLES AND THEIR THERMOSENSITIVITY [J].
DEGUCHI, S ;
AKIYOSHI, K ;
SUNAMOTO, J .
MACROMOLECULAR RAPID COMMUNICATIONS, 1994, 15 (09) :705-711
[4]  
HOVGAARD L, 1992, J CONTROL RELEASE, V19, P99, DOI 10.1016/0168-3659(92)90068-3
[5]  
KAVANOV AV, 1992, J CONTROL RELEASE, V22, P141
[6]   PHYSICAL STABILITY OF INSULIN FORMULATIONS [J].
LOUGHEED, WD ;
ALBISSER, AM ;
MARTINDALE, HM ;
CHOW, JC ;
CLEMENT, JR .
DIABETES, 1983, 32 (05) :424-432
[7]   STRUCTURE AND STABILITY OF INSULIN DISSOLVED IN 1-OCTANOL [J].
MATSUURA, J ;
POWERS, ME ;
MANNING, MC ;
SHEFTER, E .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (04) :1261-1264
[8]   AGGREGATE OF AMPHIPHILIC BLOCK-COPOLYMER DERIVED FROM POLY[(N-ACYLIMINO)ETHYLENE]S AND GUEST-BINDING PROPERTIES FOR 8-ANILINO-1-NAPHTHALENESULFONIC ACID, PYRENE, AND ENZYMES [J].
NAKA, K ;
KUBO, Y ;
OHKI, A ;
MAEDA, S .
POLYMER JOURNAL, 1994, 26 (03) :243-249
[9]   SUPRAMOLECULAR ASSEMBLY BETWEEN NANOPARTICLES OF HYDROPHOBIZED POLYSACCHARIDE AND SOLUBLE-PROTEIN COMPLEXATION BETWEEN THE SELF-AGGREGATE OF CHOLESTEROL-BEARING PULLULAN AND ALPHA-CHYMOTRYPSIN [J].
NISHIKAWA, T ;
AKIYOSHI, K ;
SUNAMOTO, J .
MACROMOLECULES, 1994, 27 (26) :7654-7659
[10]   CONFORMATIONAL DYNAMICS OF INSULIN IN SOLUTION - CIRCULAR DICHROIC STUDIES [J].
POCKER, Y ;
BISWAS, SB .
BIOCHEMISTRY, 1980, 19 (22) :5043-5049