T-CELL RESPONSE TO STAPHYLOCOCCAL SUPERANTIGENS BY ASYMPTOMATIC HIV-INFECTED INDIVIDUALS EXHIBITS SELECTIVE CHANGES IN T-CELL RECEPTOR V(BETA)-CHAIN USAGE

被引:16
作者
BISSET, LR [1 ]
OPRAVIL, M [1 ]
LUDWIG, E [1 ]
FIERZ, W [1 ]
机构
[1] UNIV HOSP, DEPT INTERNAL MED, INFECT DIS SECT, CH-8044 ZURICH, SWITZERLAND
关键词
D O I
10.1089/aid.1993.9.241
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recognition that the murine mammary tumor C-type retrovirus and the replication-defective murine leukemia virus have ''superantigen'' properties raises the specter that human immunodeficiency virus might also generate T cell impairment and destruction as a result of inherent superantigen properties. The observation that individuals with AIDS lack the expression of several T cell receptor V(beta)-chain genes lends support to this hypothesis. Staphylococcal exotoxins represent another class of superantigen with a similar ability to stimulate large numbers of T cells bearing specific T cell receptor V(beta)-chain types. To examine the hypothesis that T cells from HIV-infected individuals may be exposed to a superantigen during the infection process, we have compared the ability of T cells from asymptomatic HIV-infected donors and healthy donors to respond to stimulation with several known staphylococcal exotoxin superantigens. Following in vitro stimulation with staphylococcal enterotoxin D and staphylococcal enterotoxin E, asymptomatic HIV-infected individuals responded with a significantly different T cell receptor V(beta)-chain usage to that observed for healthy individuals. This skewed V(beta)-chain usage is likely to reflect preferential conditioning of T cells bearing specific V(beta)-chains as a result of HIV infection, supporting the hypothesis of superantigen involvement early in the course of infection.
引用
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页码:241 / 246
页数:6
相关论文
共 41 条
[1]   CLONAL DELETION OF V-BETA 14-BEARING T-CELLS IN MICE TRANSGENIC FOR MAMMARY-TUMOR VIRUS [J].
ACHAORBEA, H ;
SHAKHOV, AN ;
SCARPELLINO, L ;
KOLB, E ;
MULLER, V ;
VESSAZSHAW, A ;
FUCHS, R ;
BLOCHLINGER, K ;
ROLLINI, P ;
BILLOTTE, J ;
SARAFIDOU, M ;
MACDONALD, HR ;
DIGGELMANN, H .
NATURE, 1991, 350 (6315) :207-211
[2]  
BARKER JW, 1988, AM CLIN LAB, V10, P32
[3]   ABROGATION OF RESISTANCE TO SEVERE MOUSEPOX IN C57BL/6 MICE INFECTED WITH LP-BM5 MURINE LEUKEMIA VIRUSES [J].
BULLER, RML ;
YETTER, RA ;
FREDRICKSON, TN ;
MORSE, HC .
JOURNAL OF VIROLOGY, 1987, 61 (02) :383-387
[4]   B-CELLS ARE REQUIRED FOR INDUCTION OF T-CELL ABNORMALITIES IN A MURINE RETROVIRUS-INDUCED IMMUNODEFICIENCY SYNDROME [J].
CERNY, A ;
HUGIN, AW ;
HARDY, RR ;
HAYAKAWA, K ;
ZINKERNAGEL, RM ;
MAKINO, M ;
MORSE, HC .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (01) :315-320
[5]   SUPERANTIGENS [J].
CHATILA, T ;
GEHA, RS .
CURRENT OPINION IN IMMUNOLOGY, 1992, 4 (01) :74-78
[6]  
CHIRMULE N, 1990, BLOOD, V75, P152
[7]  
CHIRMULE N, 1988, J ACQ IMMUN DEF SYND, V1, P425
[8]   INTERACTION OF STAPHYLOCOCCUS-AUREUS TOXIN SUPERANTIGENS WITH HUMAN T-CELLS [J].
CHOI, YW ;
KOTZIN, B ;
HERRON, L ;
CALLAHAN, J ;
MARRACK, P ;
KAPPLER, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8941-8945
[9]   A SUPERANTIGEN ENCODED IN THE OPEN READING FRAME OF THE 3' LONG TERMINAL REPEAT OF MOUSE MAMMARY-TUMOR VIRUS [J].
CHOI, YW ;
KAPPLER, JW ;
MARRACK, P .
NATURE, 1991, 350 (6315) :203-207
[10]   INTERLEUKIN-2 PRODUCTION USED TO DETECT ANTIGENIC PEPTIDE RECOGNITION BY T-HELPER LYMPHOCYTES FROM ASYMPTOMATIC HIV-SEROPOSITIVE INDIVIDUALS [J].
CLERICI, M ;
STOCKS, NI ;
ZAJAC, RA ;
BOSWELL, RN ;
BERNSTEIN, DC ;
MANN, DL ;
SHEARER, GM ;
BERZOFSKY, JA .
NATURE, 1989, 339 (6223) :383-385