SYNTHESIS OF THYMIDINE DIMER DERIVATIVES CONTAINING AN AMIDE LINKAGE AND THEIR INCORPORATION INTO OLIGODEOXYRIBONUCLEOTIDES

被引：74

作者：

LEBRETON, J ^{[1
]}

DEMESMAEKER, A ^{[1
]}

WALDNER, A ^{[1
]}

FRITSCH, V ^{[1
]}

WOLF, RM ^{[1
]}

FREIER, SM ^{[1
]}

机构：

[1] ISIS PHARMACEUT INC,CARLSBAD,CA 92008

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 40期

关键词：

D O I：

10.1016/0040-4039(93)85051-W

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of thymidine dimers in which the natural phosphodiester linkage has been replaced by an amide group (3'-NR-CO-CH2-5', R=H, Me, n-Pr) are described. These new dimers were incorporated into oligonucleotides. Measurement of melting temperatures (T(m)) of DNA/RNA duplexes and the nuclease resistance are presented. Preliminary results of molecular mechanics calculations are included.

引用

页码：6383 / 6386

页数：4

共 17 条

[1] STEREOSELECTIVITY IN RADICAL REACTIONS OF 2'-DEOXYNUCLEOSIDES - A SYNTHESIS OF AN ISOSTERE OF 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE (AZT-5'MONOPHOSPHATE) [J].