SCOPOLAMINE INJECTED INTO THE RAT AMYGDALA IMPAIRS WORKING-MEMORY IN THE DOUBLE Y-MAZE

被引:38
作者
INGLES, JL
BENINGER, RJ
JHAMANDAS, K
BOEGMAN, RJ
机构
[1] QUEENS UNIV,DEPT PSYCHOL,KINGSTON K7L 3N6,ONTARIO,CANADA
[2] QUEENS UNIV,DEPT PHARMACOL & TOXICOL,KINGSTON K7L 3N6,ONTARIO,CANADA
关键词
ACETYLCHOLINE; AMYGDALA; DOUBLE Y-MAZE; NUCLEUS BASALIS MAGNOCELLULARIS; REFERENCE MEMORY; SCOPOLAMINE; WORKING MEMORY;
D O I
10.1016/0361-9230(93)90197-J
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent neurochemical results suggest the hypothesis that the nucleus basalis magnocellularis (nbm) cholinergic projection to the amygdala may play a role in memory. The present study investigated the effects of intraamygdaloid injections of the cholinergic antagonist scopolamine on working and reference memory in the double Y-maze. Rats were pretrained until working and reference memory choice accuracy stabilized to a criterion of greater-than-or-equal-to 86% correct. Bilateral cannulae were then surgically implanted in the basolateral amygdaloid complex. Rats (n = 9) received scopolamine in doses of 8.0, 24.0, and 72.0 mug/0.5 Al and saline (0.5 mul) in a counterbalanced order with retraining to criterion between injections. Intraamygdaloid scopolamine produced a dose-dependent and differential impairment of working and reference memory. A dose of 24.0 mug impaired working memory without significantly affecting reference memory; doses of 8.0 mug and 72.0 mug affected neither and both types of memory, respectively. Results implicate amygdaloid acetylcholine in memory.
引用
收藏
页码:339 / 344
页数:6
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