CHEMICAL OXIDATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) AND ITS INVIVO METABOLISM IN RAT-BRAIN AND LIVER

被引：20

作者：

ARORA, PK

RIACHI, NJ

HARIK, SI

SAYRE, LM

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106

[2] CASE WESTERN RESERVE UNIV,DEPT NEUROL,CLEVELAND,OH 44106

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1988年 / 152卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(88)80432-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

收藏

页码：1339 / 1347

页数：9

相关论文

共 26 条

[11] Johannessen J. N., 1986, MPTP NEUROTOXIN PROD, P173
[12] BLOOD-BRAIN-BARRIER MONOAMINE-OXIDASE - ENZYME CHARACTERIZATION IN CEREBRAL MICROVESSELS AND OTHER TISSUES FROM 6 MAMMALIAN-SPECIES, INCLUDING HUMAN
KALARIA, RN
HARIK, SI
[J]. JOURNAL OF NEUROCHEMISTRY, 1987, 49 (03) : 856 - 864
[13] PREPARATION AND SOME REACTIONS OF 1-METHYL-4-PHENYL-3,4-EPOXYPIPERIDINE
LYLE, RE
KRUEGER, WE
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (02) : 394 - &
[14] NUCLEOPHILIC OPENING OF OXIRANE RING OF 1-METHYL-4-PHENYL-3,4-EPOXYPIPERIDINE
LYLE, RE
KRUEGER, WE
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (09) : 2873 - &
[15] Markey S. P., 1986, MPTP NEUROTOXIN PROD
[16] INTRANEURONAL GENERATION OF A PYRIDINIUM METABOLITE MAY CAUSE DRUG-INDUCED PARKINSONISM
MARKEY, SP
JOHANNESSEN, JN
CHIUEH, CC
BURNS, RS
HERKENHAM, MA
[J]. NATURE, 1984, 311 (5985) : 464 - 467
[17] NAGAI Y, 1980, CHEM PHARM BULL, V28, P1387
[18] RAJAGOPALAN KV, 1964, J BIOL CHEM, V239, P2027
[19] RIACHI NJ, 1988, J PHARMACOL EXP THER, V244, P443
[20] FORMATION OF A REACTIVE IMINIUM DERIVATIVE BY ENZYMATIC AND CHEMICAL OXIDATIONS OF 16-O-ACETYLVINDOLINE
SARIASLANI, FS
ECKENRODE, FM
BEALE, JM
ROSAZZA, JP
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (06) : 749 - 754