EFFECTS OF 5-HT3 RECEPTOR ANTAGONISTS ON MODELS OF ACUTE AND DELAYED EMESIS INDUCED BY CISPLATIN IN THE FERRET

被引：43

作者：

RUDD, JA

NAYLOR, RJ

机构：

[1] Postgraduate Studies in Pharmacology, The School of Pharmacy, University of Bradford, Bradford

来源：

NEUROPHARMACOLOGY | 1994年 / 33卷 / 12期

关键词：

EMESIS; DELAYED; 5-HT3; RECEPTORS;

D O I：

10.1016/0028-3908(94)90136-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The emetic profile of action of cisplatin 5 and 10 mg/kg i.p. was investigated in the ferret over a 72 and 24hr period respectively. The 5-HT3 receptor antagonists ondansetron and alosetron markedly antagonized or abolished the emesis during the ''acute phase'' and, whilst antagonizing the emesis during the delayed phase, also revealed a 5-HT3 receptor antagonist resistant component. These cisplatin paradigms may provide models relevant to the study of acute and delayed emesis induced by cisplatin in man.

引用

页码：1607 / 1608

页数：2