ASYMMETRIC HECK REACTION OF ALKENYL IODIDES IN THE PRESENCE OF SLIVER SALTS - CATALYTIC ASYMMETRIC-SYNTHESIS OF DECALIN AND FUNCTIONALIZED INDOLIZIDINE DERIVATIVES

被引:86
作者
SATO, Y
NUKUI, S
SODEOKA, M
SHIBASAKI, M
机构
[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO,TOKYO 113,JAPAN
[2] HOKKAIDO UNIV,FAC PHARMACEUT SCI,KITA KU,SAPPORO 060,HOKKAIDO,JAPAN
关键词
D O I
10.1016/S0040-4020(01)80761-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Decalin derivatives 3 (up to 80% ee) and indolizidine derivative 6 (up to 86% ee) have been synthesized by an asymmetric Heck reaction starling with prochiral alkenyl iodides 1 and 4, respectively. The important role of silver salts in the asymmetric Heck reaction is discussed, and the conversion of 6 to delta-coniceine (24) is also described.
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页码:371 / 382
页数:12
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