USE OF A LUCIFERASE REPORTER SYSTEM FOR CHARACTERIZING G-PROTEIN-LINKED RECEPTORS

被引：28

作者：

STRATOWA, C

HIMMLER, A

CZERNILOFSKY, AP

机构：

[1] Molecular Biology Department, Boehringer Ingelheim Research Vienna, Bender and Company, A-1121 Vienna

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1995年 / 6卷 / 05期

关键词：

D O I：

10.1016/0958-1669(95)80095-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

During the past few years, the molecular cloning of G-protein-linked receptors has revealed new opportunities for their study. Functional coupling of the seven transmembrane domain receptors to reporter genes has assisted in the molecular and pharmacological characterization of these receptors, in the evaluation of signal transduction pathways, in the cloning of new receptor subtypes, and in the development of advanced drug screening systems based on functional assays.

引用

收藏

页码：574 / 581

页数：8

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