PRODUCTION OF OXYTETRACYCLINE BY IMMOBILIZED STREPTOMYCES-RIMOSUS CELLS IN CALCIUM ALGINATE GELS

被引：14

作者：

FARID, MA

ELDIWANY, AL

ELENSHASHY, HA

机构：

[1] National Research Centre Natural, Microbial Products Department, Cairo, El-Tahrir Street Dokki

来源：

ACTA BIOTECHNOLOGICA | 1994年 / 14卷 / 03期

关键词：

D O I：

10.1002/abio.370140316

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptomyces rimosus Pfizer 18234-2 cells were immobilized in calcium alginate and used for the production of oxytetracycline. The influence of the incubation period, alginate concentration and storage in CaCl2 were investigated. From the results of the repeated batch fermentations of the shake flasks, a good level of antibiotic was maintained for a period of about 28 days using 4% calcium alginate. The cell leakage and cell concentration inside the beads were affected by the alginate concentration and storage in CaCl2 solution.

引用

页码：303 / 309

页数：7

共 23 条

[1]

ABOUZEID AA, 1981, J AGR WASTES, V3, P257

[2]

BABIC J, 1968, MIKROBIOLOGIYA, V5, P157

[3] CREAM FERMENTATION BY IMMOBILIZED LACTIC-ACID BACTERIA [J].