THE CELLULAR IMMUNE-RESPONSE TO HEAT-SHOCK PROTEINS

被引：38

作者：

KAUFMANN, SHE

机构：

[1] Department of Immunology, University of Ulm, Ulm, D-7900

来源：

EXPERIENTIA | 1992年 / 48卷 / 07期

关键词：

LYMPHOCYTE-T; HEAT SHOCK PROTEIN; MYCOBACTERIA; SCAVENGER FUNCTION; AUTOIMMUNE DISEASE;

D O I：

10.1007/BF02118309

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

T lymphocytes, which are central to almost every immune response, frequently recognize microbial hsp60. Such cells could provide an early defense mechanism against pathogenic microbes. However, T cells also recognize epitopes of hsp60 shared by microbe and host. Not only conventional alpha/beta T cells respond to hsp60; gamma/delta T cells do so, as well. In fact, certain gamma/delta T cells seem to have a particular preference for this molecule. Recognition of stressed host cells expressing hsp60 could facilitate the scavenger function of the T cell system. On the other hand, such recognition could be involved in autoimmune disease.

引用

收藏

页码：640 / 643

页数：4

相关论文

共 38 条

[21] THE ROLE OF T-CELL - MACROPHAGE INTERACTIONS IN TUBERCULOSIS [J].

KAUFMANN, SHE ;

FLESCH, IEA .

SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1988, 10 (04) :337-358

[22] ENUMERATION OF T-CELLS REACTIVE WITH MYCOBACTERIUM-TUBERCULOSIS ORGANISMS AND SPECIFIC FOR THE RECOMBINANT MYCOBACTERIAL 64-KDA PROTEIN [J].

KAUFMANN, SHE ;

VATH, U ;

THOLE, JER ;

VANEMBDEN, JDA ;

EMMRICH, F .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (03) :351-357

[23]

KAUFMANN SHE, 1991, CURR TOP MICROBIOL I, V167

[24] T-CELLS AGAINST A BACTERIAL HEAT-SHOCK PROTEIN RECOGNIZE STRESSED MACROPHAGES [J].

KOGA, T ;

WANDWURTTENBERGER, A ;

DEBRUYN, J ;

MUNK, ME ;

SCHOEL, B ;

KAUFMANN, SHE .

SCIENCE, 1989, 245 (4922) :1112-1115

[25] CELL BIOLOGY OF CYTO-TOXIC AND HELPER T-CELL FUNCTIONS - IMMUNOFLUORESCENCE MICROSCOPIC STUDIES OF SINGLE CELLS AND CELL COUPLES [J].

KUPFER, A ;

SINGER, SJ .

ANNUAL REVIEW OF IMMUNOLOGY, 1989, 7 :309-337

[26]

Lamb J R, 1989, Int Immunol, V1, P191, DOI 10.1093/intimm/1.2.191

[27] T-CELL RECOGNITION OF BACTERIAL HEAT-SHOCK PROTEINS IN INFLAMMATORY ARTHRITIS [J].

LIFE, PF ;

BASSEY, EOE ;

GASTON, JSH .

IMMUNOLOGICAL REVIEWS, 1991, 121 :113-135

[28]

MUNK ME, 1989, J IMMUNOL, V143, P2844

[29] STIMULATION OF A MAJOR SUBSET OF LYMPHOCYTES EXPRESSING T-CELL RECEPTOR-GAMMA-DELTA BY AN ANTIGEN DERIVED FROM MYCOBACTERIUM-TUBERCULOSIS [J].

OBRIEN, RL ;

HAPP, MP ;

DALLAS, A ;

PALMER, E ;

KUBO, R ;

BORN, WK .

CELL, 1989, 57 (04) :667-674

[30] PATHOGENIC ANTI-DNA AUTOANTIBODY-INDUCING T-HELPER CELL-LINES FROM PATIENTS WITH ACTIVE LUPUS NEPHRITIS - ISOLATION OF CD4-8- T-HELPER CELL-LINES THAT EXPRESS THE GAMMA-DELTA-T-CELL ANTIGEN RECEPTOR [J].

RAJAGOPALAN, S ;

ZORDAN, T ;

TSOKOS, GC ;

DATTA, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :7020-7024

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