COMPARATIVE-ANALYSIS OF SCRAPIE AGENT INACTIVATION METHODS

被引：91

作者：

ERNST, DR

RACE, RE

机构：

[1] National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton

来源：

JOURNAL OF VIROLOGICAL METHODS | 1993年 / 41卷 / 02期

关键词：

SCRAPIE; LPH; SPONGIFORM ENCEPHALOPATHY; NEURO-DEGENERATIVE; KURU; GERSTMANN-STRAUSSLER-SCHEINKER DISEASE; CREUTZFELDT-JAKOB DISEASE;

D O I：

10.1016/0166-0934(93)90126-C

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A scrapie-infected hamster brain homogenate was subjected to several different potential inactivation methods. Methods included autoclaving for various lengths of time, either alone or in combination with different concentrations of sodium hydroxide or LpH, an aqueous acid phenolic derivative (Calgon Vestal Laboratories in St. Louis, MO). Inactivation treatments utilizing either NaOH or LpH alone were also evaluated. It was determined that several of the treatments inactivated all of the detectable infectivity.

引用

页码：193 / 201

页数：9