CHEMOENZYMATIC PREPARATION OF ATROLACTIC AND MOSHERS ACID USING ASPERGILLUS-ORYZAE PROTEASE

被引：22

作者：

FEICHTER, C

FABER, K

GRIENGL, H

机构：

[1] Christian Doppler Laboratory for Chiral Compounds, Institute of Organic Chemistry, Graz University of Technology, A-8010 Graz

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 03期

关键词：

D O I：

10.1039/p19910000653

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sterically demanding alpha-methyl- and alpha-trifluoromethyl-mandelic esters 5a and 6a were conveniently resolved on a large scale by a protease from Aspergillus oryzae leading to both enantiomers of atrolactic acid 5b and a precursor of Mosher's acid 6b in 75-88% e.e. Single recrystallisation led to optically pure material.

引用

页码：653 / 654

页数：2