THE LOCUS CONTROLLING PINEAL SEROTONIN N-ACETYLTRANSFERASE ACTIVITY (NAT-2) IS LOCATED ON MOUSE CHROMOSOME-11

被引：26

作者：

GOTO, M ^{[1
]}

OSHIMA, I ^{[1
]}

HASEGAWA, M ^{[1
]}

EBIHARA, S ^{[1
]}

机构：

[1] NAGOYA UNIV,FAC AGR,DEPT ANIM PHYSIOL,CHIKUSA KU,NAGOYA 464,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 21卷 / 3-4期

关键词：

MELATONIN DEFICIENCY; SEROTONIN N-ACETYLTRANSFERASE; HYDROXYINDOLE-O-METHYLTRANSFERASE; RECOMBINANT INBRED STRAIN; GENE MAPPING; CIRCADIAN RHYTHM;

D O I：

10.1016/0169-328X(94)90266-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Melatonin is synthesized from serotonin by the enzymes serotonin N-acetyltransferase (SNAT) and hydroxyindole-O-methyltransferase (HIOMT). We have previously reported that C57BL/6 mice do not have SNAT activity because of a mutation in an autosomal gene which is responsible for the absence of normal SNAT activity. In the present study, we have tried to map the loci of Nat-2 (the locus controlling SNAT activity) on chromosomes using a set of the BxH recombinant inbred strains which were derived from an initial cross between C3H/He with SNAT and C57BL/6 without the enzyme. Based on strain distribution patterns (SDPs), a close linkage on chromosome 11 was found between Naf-2, Es-3 (esterase-3), Glk (the locus controlling galactokinase activity) and Myla (myosin alkali light chains expressed in cardiac atrial muscle). The linkage between Nat-2 and Es-3 was confirmed by a conventional linkage test and the recombination frequency between these loci was estimated to be 16.1 +/- 3.6% (mean +/- S.E.M.).

引用

页码：349 / 354

页数：6