RNA-POLYMERASE I-MEDIATED PROTEIN-CODING GENE-EXPRESSION IN TRYPANOSOMA-BRUCEI

被引：51

作者：

CHUNG, HM

LEE, MGS

VANDERPLOEG, LHT

机构：

[1] COLUMBIA UNIV, DEPT GENET & DEV, NEW YORK, NY 10032 USA

[2] COLUMBIA UNIV, SCH PUBL HLTH, DIV TROP MED, NEW YORK, NY 10032 USA

来源：

PARASITOLOGY TODAY | 1992年 / 8卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0169-4758(92)90194-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Protein-coding genes are transcribed by RNA polymerase (pol) II in all eukaryotes analyzed to date, with the exception of the protozoan Trypanosoma brucei, where pol I can mediate expression of chloramphenicol acetyl transferase (CAT) and neomycin phosphotransferase (neo) reporter genes. The addition of the capped 39-nucleotide (nt) mini-exon to the pre-messenger RNA (mRNA) by trans-splicing in T. brucei has presumably led to the uncoupling of the requirement for production of mRNA by pol II. Here Hui-min Chung Mary G-S. Lee and Lex Van der Ploeg review the evidence that supports the notion that pol I also transcribes a subset of naturally occurring protein-coding genes in T. brucei.

引用

页码：414 / 418

页数：5

共 43 条

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