A SIMPLE AND HIGHLY STEREOSELECTIVE ROUTE TO A KEY INTERMEDIATE CARBOXYLIC-ACID FOR THE SYNTHESIS OF 1-BETA-METHYLCARBAPENEMS

被引：8

作者：

MORI, M ^{[1
]}

OIDA, S ^{[1
]}

机构：

[1] SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80961-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple and highly stereoselective synthesis of 1, starting from the acetoxyazetidinone 4, via oxidative degradation of the intermediate ketone 12 was developed.

引用

页码：2389 / 2392

页数：4

共 9 条

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[7] A NOVEL CARBAPENEM ANTIBIOTIC, SM-7338 STRUCTURE-ACTIVITY-RELATIONSHIPS
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[8] A SIMPLE AND STEREOCONTROLLED SYNTHESIS OF A 1-BETA-METHYLCARBAPENEM KEY INTERMEDIATE BY MEANS OF ORGANOSILICON CHEMISTRY
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