THE EFFECT OF ANTIOXIDANTS ON BLEOMYCIN TREATMENT IN IN-VITRO AND IN-VIVO GENOTOXICITY ASSAYS

被引：48

作者：

ANDERSON, D ^{[1
]}

BASARAN, N ^{[1
]}

BLOWERS, SD ^{[1
]}

EDWARDS, AJ ^{[1
]}

机构：

[1] HACETTEPE UNIV,FAC PHARM,DEPT PHARMACEUT TOX,ANKARA 06100,TURKEY

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1995年 / 329卷 / 01期

关键词：

D O I：

10.1016/0027-5107(95)00017-D

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Antioxidants are thought to be important in protecting against damage from active oxygen species. The effects of the antioxidant nutrients vitamins C and E have been investigated after bleomycin treatment in the Salmonella typhimurium bacterial mutation assay, in the human peripheral lymphocyte chromosome aberration assay, and in the mouse micronucleus assay in peripheral blood and bone marrow cells. There were no protective effects from vitamins C and E in the bacterial mutation assay, but vitamin C and not vitamin E abolished chromosome damaging responses in human peripheral lymphocytes, and both vitamins reduced responses in micronuclei from peripheral blood cells in mice. This would suggest that in human cells in vitro and mouse cells in vivo these vitamins could have a protective role.

引用

页码：37 / 47

页数：11

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