METABOLIC FATES OF GRAMINE IN BARLEY .2. BIOTRANSFORMATION OF GRAMINE INTO INDOLE-3-CARBINOL AND INDOLE-3-CARBOXYLIC ACID IN BARLEY

被引：9

作者：

DIGENIS, GA

机构：

[1] Departments of Materia Medica and Pharmaceutical Chemistry, College of Pharmacy, University of Kentucky, Lexington, Kentucky

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 01期

关键词：

Biotransformation—radiolabeled gramine; Gramine in barley—metabolism; Liquid scintillation counting—radioactivity determination; Metabolites; gramine—isolated; identified; TLC—separation; identity;

D O I：

10.1002/jps.2600580105

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

When gramine, labeled in the methylenic side chain with both 14C and tritium, was administered to 60‐day‐old barley shoots, it was biotransformed to indole‐3‐carbinol and indole‐3‐carboxylic acid. A mechanism involving an indolenine intermediate is proposed. The mechanism is reminiscent of the stepwise degradation of serotonin to 5‐hydroxyindoleacetic acid in man and suggests that enzymes capable of biodegrading the side chain of indoles may be common to both the animal and plant kingdoms. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：42 / &

共 15 条

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