INTERLEUKIN-6 IN CLINICAL MEDICINE

被引:135
作者
BAUER, J
HERRMANN, F
机构
[1] UNIV FREIBURG, MED KLIN, INNERE MED ABT 1, HUGSTETTER STR 55, W-7800 FREIBURG, GERMANY
[2] UNIV FREIBURG, PSYCHIAT KLIN, W-7800 FREIBURG, GERMANY
关键词
INTERLEUKIN-6; INFLAMMATION; ACUTE PHASE RESPONSE; HEMATOPOIESIS LEUKEMIA; TUMOR;
D O I
10.1007/BF01729833
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This article covers the basic biological functions of interleukin-6 (IL-6) in man. Three major topics are addressed more closely: the involvement of IL-6 in various disease states, particularly those of hematopoietic origin; the diagnostic usefulness of IL-6 measurements in biological fluids; the possible use of IL-6, IL-6 antagonists or IL-6 derivatives as therapeutic means.
引用
收藏
页码:203 / 210
页数:8
相关论文
共 110 条
[1]   PRODUCTION OF HYBRIDOMA GROWTH-FACTOR BY HUMAN-MONOCYTES [J].
AARDEN, LA ;
DEGROOT, ER ;
SCHAAP, OL ;
LANSDORP, PM .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (10) :1411-1416
[2]   BIOLOGY OF MULTIFUNCTIONAL CYTOKINES - IL-6 AND RELATED MOLECULES (IL-1 AND TNF) [J].
AKIRA, S ;
HIRANO, T ;
TAGA, T ;
KISHIMOTO, T .
FASEB JOURNAL, 1990, 4 (11) :2860-2867
[3]  
ANDUS T, 1991, IN PRESS PATHOBIOL
[4]  
ASANO S, 1990, BLOOD, V75, P1602
[5]  
ASAOKU H, 1988, BLOOD, V72, P429
[6]   SERUM LEVELS OF INTERLEUKIN-6, A POTENT MYELOMA CELL-GROWTH FACTOR, AS A REFLECT OF DISEASE SEVERITY IN PLASMA-CELL DYSCRASIAS [J].
BATAILLE, R ;
JOURDAN, M ;
ZHANG, XG ;
KLEIN, B .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (06) :2008-2011
[7]  
BAUER J, 1988, BLOOD, V72, P1134
[8]   REGULATION OF INTERLEUKIN-6 RECEPTOR EXPRESSION IN HUMAN-MONOCYTES AND MONOCYTE-DERIVED MACROPHAGES - COMPARISON WITH THE EXPRESSION IN HUMAN HEPATOCYTES [J].
BAUER, J ;
BAUER, TM ;
KALB, T ;
TAGA, T ;
LENGYEL, G ;
HIRANO, T ;
KISHIMOTO, T ;
ACS, G ;
MAYER, L ;
GEROK, W .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (05) :1537-1549
[9]   INTERLEUKIN-6 AND ITS RECEPTOR DURING HOMEOSTASIS, INFLAMMATION, AND TUMOR-GROWTH [J].
BAUER, J .
KLINISCHE WOCHENSCHRIFT, 1989, 67 (14) :697-706
[10]   INTERLEUKIN-1-BETA INDUCES SYNTHESIS AND SECRETION OF INTERLEUKIN-6 IN HUMAN CHONDROCYTES [J].
BENDER, S ;
HAUBECK, HD ;
VANDELEUR, E ;
DUFHUES, G ;
SCHIEL, X ;
LAUWERIJNS, J ;
GREILING, H ;
HEINRICH, PC .
FEBS LETTERS, 1990, 263 (02) :321-324