CGS5649B, A NEW COMPOUND, REVERSES AGE-RELATED COGNITIVE DYSFUNCTIONS IN RATS

被引：3

作者：

MONDADORI, C

BUERKI, H

BORKOWSKI, J

RADEKE, E

DUCRET, T

GLATT, A

机构：

[1] Pharmaceutical Research Department, Ciba-Geigy Limited, Basel

来源：

BEHAVIORAL AND NEURAL BIOLOGY | 1992年 / 57卷 / 02期

关键词：

D O I：

10.1016/0163-1047(92)90653-L

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

CGS 5649 B improves the learning performance of aged rats in a one-way active-avoidance situation. If, under reversed conditions, treated aged rats are also tested for passive avoidance, they show "place learning," which our findings have demonstrated to be typical of young rats. The effects of the substance are not confined to these experimental models nor are they species specific: it also facilitates passive avoidance in mice and social learning in rats. The compound is effective if administered before or immediately after the learning trial. © 1992 Academic Press, Inc.

引用

页码：149 / 156

页数：8

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