(31)PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY OF THE FRONTAL AND PARIETAL LOBES IN CHRONIC-SCHIZOPHRENIA

被引:95
作者
DEICKEN, RF
CALABRESE, G
MERRIN, EL
MEYERHOFF, DJ
DILLON, WP
WEINER, MW
FEIN, G
机构
[1] VET AFFAIRS MED CTR,MAGNET RESONANCE UNIT,SAN FRANCISCO,CA 94121
[2] UNIV CALIF SAN FRANCISCO,DEPT RADIOL,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA
[4] UNIV CALIF SAN FRANCISCO,DEPT PSYCHIAT,SAN FRANCISCO,CA 94143
[5] UNIV MILAN,HS RAFFAELE INST,DEPT PSYCHIAT,MILAN,ITALY
关键词
MAGNETIC RESONANCE SPECTROSCOPY; SCHIZOPHRENIA; PHOSPHORUS; PHOSPHOLIPID; FRONTAL LOBE; BRAIN METABOLISM;
D O I
10.1016/0006-3223(94)90613-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In vivo (31)Phosphorus magnetic resonance spectroscopic imaging (P-31 MRSI) was performed on 20 chronic schizophrenic patients and 16 normal controls to determine if there were specific changes in high energy phosphorous and phospholipid metabolism in the frontal lobes of schizophrenic patients. Phosphorous metabolites were assessed in each of the left and right frontal as well as the left and right parietal lobes. Frontal lobe phosphorous metabolites were also correlated with severity of psychiatric symptomatology as assessed by the Brief Psychiatric Rating Scale (BPRS). Schizophrenics demonstrated higher phosphodiesters (PDE) and lower phosphocreatine (PCr) in both the left and right frontal regions compared to controls. There was also lower left frontal inorganic phosphate (Pi) in the schizophrenic group. No group differences were noted in the left or right parietal regions. In addition, right frontal PDE and right frontal PCr were highly correlated with the hostility-suspiciousness and anxiety-depression subscales of the BPRS. This study provides further support for altered frontal lobe phosphorous metabolism in schizophrenia.
引用
收藏
页码:503 / 510
页数:8
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