ON THE OPTIMIZATION OF PIG PANCREATIC LIPASE-CATALYZED MONOACETYLATION OF PROCHIRAL DIOLS

被引：30

作者：

BANFI, L ^{[1
]}

GUANTI, G ^{[1
]}

RIVA, R ^{[1
]}

机构：

[1] CNR,CTR STUDIO CHIM COMPOSTI CICLOALIFATICI & AROMATI,I-16132 GENOA,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 06期

关键词：

D O I：

10.1016/0957-4166(95)00167-N

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The effect of various experimental variables (solvent, methodology of supportation on celite, presence of water, conversion and so on) on the rate and on the enantioselectivity of monoacetylation of some prochiral 2-substituted-1,3-propanediols with vinyl acetate catalyzed by crude PPL (pig pancreatic lipase) was analyzed. This study allowed to assess the best conditions for performing these transformations, providing an efficient methodology for the synthesis of valuable chiral building blocks with moderate amounts of inexpensive PPL, which can also be easily recycled.

引用

页码：1345 / 1356

页数：12