DELAYED NEUROTOXICITY OF O-ETHYL O-4-CYANOPHENYL PHENYLPHOSPHONOTHIOATE (CYANOFENPHOS) IN HENS

Oral administration of a single dose of cyanofenphos (O-ethyl O-4-cyano-phenyl phenylphosphonothioate) between 10 and 500 mg/kg, caused delayed neurotoxocity in hens similar to that reported for other organophosphorus esters. The severity of the clinical condition depended upon the size of the administered dose. Hens given small doses showed only ataxia, while some of those treated with large doses developed paralysis and died. Hens given 500 mg/kg oral dose of tri-o-cresyl phosphate (TOCP) became paralysed, while those given parathion showed early weakness but subsequently recovered without developing delayed neurotoxicity. Control hens receiving atropine sulfate or gelatin capsules remained normal. © 1979.