GENES ENCODING THE PLATELET-DERIVED GROWTH-FACTOR (PDGF) RECEPTOR AND COLONY-STIMULATING FACTOR-I (CSF-1) RECEPTOR ARE PHYSICALLY ASSOCIATED IN MICE AS IN HUMANS

被引：6

作者：

ECCLES, MR

机构：

[1] Molecular Carcinogenesis Laboratory Department of Biochemistry, University of Otago

来源：

GENE | 1991年 / 108卷 / 02期

关键词：

GROWTH FACTORS; GENE EVOLUTION; PULSED-FIELD GEL ELECTROPHORESIS; MOUSE CHROMOSOME-18; SYNTENY WITH HUMAN CHROMOSOME-5Q;

D O I：

10.1016/0378-1119(91)90447-J

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The BALB/c mouse DNA was analyzed by field-inversion gel electrophoresis to determine the orientation and distance between the beta-platelet-derived growth factor receptor-encoding gene (Pdgfr) and the colony-stimulating factor 1 receptor-encoding gene (Csfmr). It was found that the 5' portion of the Pdgfr gene was cleaved by the enzyme ClaI into two fragments. The 425-kb fragment hybridized with a 3' Pdgfr and a 5' Csfmr probe. This result shows that the Csfmr gene is 3' relative to the Pdgfr gene, and suggests that the Pdgfr and Csfmr genes are physically linked.

引用

页码：285 / 288

页数：4

共 14 条

[11] GENETIC-MAPPING OF THE GENE FOR CA-2+ CALMODULIN-DEPENDENT PROTEIN KINASE-IV (CAMK-4) TO MOUSE CHROMOSOME-18 [J].