6-SUBSTITUTED 5-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRAZIN-2-ONES WITH HYPOTENSIVE ACTIVITY

被引：14

作者：

JONES, JH ^{[1
]}

HOLTZ, WJ ^{[1
]}

CRAGOE, EJ ^{[1
]}

机构：

[1] MERCK SHARP & DOHME RES LABS,W POINT,PA 19486

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1973年 / 16卷 / 05期

关键词：

D O I：

10.1021/jm00263a029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：537 / 542

页数：6

共 9 条

[1] PYRAZINE DIURETICS .2. N-AMIDINO-3-AMINO-5-SUBSTITUTED L-HALOPYRAZINECARBOXAMIDES [J].

CRAGOE, EJ ;

WOLTERSDORF, OW ;

BICKING, JB ;

KWONG, SF ;

JONES, JH .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (01) :66-+

[2]

JOCELYN PC, 1957, J CHEM SOC, P3305

[3] DECOMPOSITION AND ADDITION REACTIONS OF ORGANIC AZIDES [J].

LABBE, G .

CHEMICAL REVIEWS, 1969, 69 (03) :345-&

[4] INHIBITION OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE PHOSPHODIESTERASE BY SUBSTITUTED IMIDAZOPYRAZINES [J].

MANDEL, LR .

BIOCHEMICAL PHARMACOLOGY, 1971, 20 (12) :3413-&

[5]

MARTIN RH, 1959, B SOC CHIM BELG, V66, P136

[6] METABOLITE ANALOGS .5. PREPARATION OF SOME SUBSTITUTED PYRAZINES AND IMIDAZO [B]PYRAZINES [J].

MUEHLMANN, FL ;

DAY, AR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1956, 78 (01) :242-244

[7] STUDIES IN IMIDAZOLES .2. IMIDAZO [B] PYRAZINES [J].

SCHIPPER, E ;

DAY, AR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (02) :350-353

[8] PYRAZINE DIURETICS .6. (PYRAZINECARBOXAMIDO)GUANIDINES [J].

SHEPARD, KL ;

MASON, JW ;

WOLTERSDORF, OW ;

JONES, JH ;

CRAGOE, EJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (02) :280-+

[9]

TKACZYNSKI T, 1962, Acta Pol Pharm, V19, P277

← 1 →