GROWTH-FACTORS IN THE HUMAN PROSTATE

被引:35
作者
FIORELLI, G [1 ]
DEBELLIS, A [1 ]
LONGO, A [1 ]
PIOLI, P [1 ]
COSTANTINI, A [1 ]
GIANNINI, S [1 ]
FORTI, G [1 ]
SERIO, M [1 ]
机构
[1] UNIV FLORENCE,DEPT UROL,I-50134 FLORENCE,ITALY
关键词
D O I
10.1016/0960-0760(91)90183-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies have focused on the potential role of local polypeptide growth-regulating factors in the etiology of benign prostatic hyperplasia (BPH) and prostatic carcinoma. In our studies we confirmed the presence of specific receptors for epidermal growth factor (EGF) in prostatic tissues from patients affected by BPH. In addition, we demonstrated that specific receptors for insulin-like growth factor type I (IGF-I) are present in BPH tissues. In order to identify a possible interaction between androgens and these growth-regulating factors, we investigated the effect of testicular suppression-induced androgen withdrawal on both EGF and IGF-I receptor concentrations in prostatic tissue from patients affected by BPH treated with a long-acting luteinizing hormone-releasing hormone analog. Both EGF and IGF-I binding capacities were significantly increased after treatment. This finding suggests that in vivo IGF-I and EGF receptor levels may be under negative androgenic regulation, indicating a potential role for these growth-regulating factors in the mechanism of response to the castration-induced regression of androgen-dependent prostatic tissue. Moreover, preliminary studies indicate that in human BPH prostatic tissue multiple IGF-binding proteins (IGF-BP) are present. This finding suggests a possible role of IGF-BP in modulating IGFs biological activities at the prostate level.
引用
收藏
页码:199 / 205
页数:7
相关论文
共 31 条
  • [11] EPIDERMAL GROWTH-FACTOR AND PROSTATIC-CARCINOMA - AN IMMUNOHISTOCHEMICAL STUDY
    FOWLER, JE
    LAU, JLT
    GHOSH, L
    MILLS, SE
    MOUNZER, A
    [J]. JOURNAL OF UROLOGY, 1988, 139 (04) : 857 - 861
  • [12] HETEROGENEITY OF BINDING SUBUNITS OF THE HUMAN 150K INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN
    GELATO, MC
    GAYNES, LA
    GREENSTEIN, LA
    NISSLEY, SP
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (04) : 879 - 887
  • [13] EXPRESSION OF INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II GENES IN HUMAN SMOOTH-MUSCLE TUMORS
    HOPPENER, JWM
    MOSSELMAN, S
    ROHOLL, PJM
    LAMBRECHTS, C
    SLEBOS, RJC
    DEPAGTERHOLTHUIZEN, P
    LIPS, CJM
    JANSZ, HS
    SUSSENBACH, JS
    [J]. EMBO JOURNAL, 1988, 7 (05) : 1379 - 1385
  • [14] CHARACTERISTICS OF PROSTATE-DERIVED GROWTH-FACTORS FOR CELLS OF THE OSTEOBLAST PHENOTYPE
    KOUTSILIERIS, M
    RABBANI, SA
    BENNETT, HPJ
    GOLTZMAN, D
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (04) : 941 - 946
  • [15] IDENTIFICATION OF A CELLULAR RECEPTOR FOR TRANSFORMING GROWTH FACTOR-BETA IN RAT VENTRAL PROSTATE AND ITS NEGATIVE REGULATION BY ANDROGENS
    KYPRIANOU, N
    ISAACS, JT
    [J]. ENDOCRINOLOGY, 1988, 123 (04) : 2124 - 2139
  • [16] EXPRESSION OF TRANSFORMING GROWTH FACTOR-BETA IN THE RAT VENTRAL PROSTATE DURING CASTRATION-INDUCED PROGRAMMED CELL-DEATH
    KYPRIANOU, N
    ISAACS, JT
    [J]. MOLECULAR ENDOCRINOLOGY, 1989, 3 (10) : 1515 - 1522
  • [17] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4
    LAEMMLI, UK
    [J]. NATURE, 1970, 227 (5259) : 680 - +
  • [18] EPIDERMAL GROWTH-FACTOR BINDING AND STEROID-RECEPTOR CONTENT IN HUMAN BENIGN PROSTATIC HYPERPLASIA
    LUBRANO, C
    PETRANGELI, E
    CATIZONE, A
    SANTONATI, A
    CONCOLINO, G
    ROMBOLA, N
    FRATI, L
    DISILVERIO, F
    SCIARRA, F
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1989, 34 (1-6) : 499 - 504
  • [19] EPIDERMAL GROWTH-FACTOR RECEPTORS IN HUMAN-PROSTATE CANCER - CORRELATION WITH HISTOLOGICAL DIFFERENTIATION OF THE TUMOR
    MADDY, SQ
    CHISHOLM, GD
    BUSUTTIL, A
    HABIB, FK
    [J]. BRITISH JOURNAL OF CANCER, 1989, 60 (01) : 41 - 44
  • [20] LOCALIZATION OF EPIDERMAL GROWTH-FACTOR RECEPTORS IN THE HUMAN-PROSTATE BY BIOCHEMICAL AND IMMUNOCYTOCHEMICAL METHODS
    MADDY, SQ
    CHISHOLM, GD
    HAWKINS, RA
    HABIB, FK
    [J]. JOURNAL OF ENDOCRINOLOGY, 1987, 113 (01) : 147 - +